With aging come different symptoms and signs of skin disorders which not only include hyperpigmentation but also wrinkle. Apart from these there is increased occurrence of stretch marks and postinflammatory hyperpigmentation. These factors cause more melasma in women. Therefore, with the increase in different skin conditions the hype for skin-whitening products has significantly increased in the USA.
When it comes to wrinkles, doctors and dermatologists tend to prescribe hydroquinone cream for wrinkles. Hydroquinone is the chemical compound which has skin-bleaching properties and is derived from benzene. For ages, the chemical compound hydroquinone has been regarded as the most potent skin-whitening agent for the treatment of aging skin problems (wrinkles, age spots, etc), different forms of hyperpigmentation including postinflammatory hyperpigmentation, and sun-induced pigmentation. In the US, doctors often prescribe either over-the-counter hydroquinone creams or the prescription-strength hydroquinone formulations. Over-the-counter hydroquinone is marketed in strengths of around 2%. However the prescription-strength formulations have hydroquinone concentrations around 3-4%. But for purchasing products with 10% hydroquinone you need to approach the compounding pharmacies. Physicians often combine the hydroquinone with other actives like glycolic acid, vitamin C, retinol, and tretinoin.
To affect hyperpigmentation and age related skin problems there are different theories about the working process of hydroquinone. Some studies suggest that hydroquinone denatures melanin-protein complex and thereby causes decoloration of skin. Whereas other studies reveal that hydroquinone cream for wrinkles prevents protein synthesis that is associated with protein and also prevents enzymatic activity of tyrosinase.
However, you should not apply hydroquinone cream for prolonged durations. You can achieve best results after applying the cream for around 4-8 weeks.